Figure 5From: Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in ratsSympathetic/sensory fiber interaction in the skin of naïve rats following MMP-2/9 inhibition. Note that close appositions of ectopic sympathetic fibers (VMAT2-IR) with peptidergic nociceptive fibers (CGRP-IR) in the upper dermis were observed at the 2 week end point following repeated injections of MMP-2/9 inhibitor (MMP-2/9I.; 20 μg, i.pl.). A and B represent confocal images of the rat’s glabrous hindpaw skin in vehicle-treated and MMP-2/9 inhibitor (MMP-2/9I.; 20 μg, i.pl.) injected rats, respectively.Back to article page