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Figure 6 | Molecular Pain

Figure 6

From: Angiotensin II produces nociceptive behavior through spinal AT1 receptor-mediated p38 mitogen-activated protein kinase activation in mice

Figure 6

Alterations in spinal MAPKs phosphorylation by Ang II and the effects of losartan and PD123319. Dorsal spinal cord samples were taken 10 min after i.t. injection of Ang II (3 pmol). Phosphorylation of ERK1/2 (a), JNK (b) and p38 MAPK (c, d) were examined by Western blotting. Losartan (3 nmol) or PD123319 (3 nmol) was co-administered i.t. with Ang II. Top: representative Western blot of total- and phospho-MAPKs. Bottom: quantification of phospho-MAPKs to total-MAPKs set as 1.0 in the Ringer- or vehicle (6.8% DMSO)-treated group. Each value represents the means ± S.E.M. of 4 mice in each group. *p < 0.05 compared with Ringer or vehicle controls and #p < 0.05 compared with Ang II alone. n.s., not significant.

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Molecular Pain

ISSN: 1744-8069

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