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Figure 4 | Molecular Pain

Figure 4

From: Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons

Figure 4

Effects of NaHS on I A and I K . Currents were measured at different holding potentials. For total voltage-gated K current, the membrane potential was held at -100 mV and voltage steps were from -40 to +30 mV with 5-mV increments and 400-ms duration. For sustained Kv current (Ik), the membrane potential was held at -50 mV and the voltage steps were the same as above. Currents generated by these two protocols were subtracted to produce IA. A, An example of ITotal (left) and IK (right) of a DiI labeled TG neurons before application of NaHS. B, An example of ITotal (left) and IK (right) of the same TG neuron in Figure 4B 3 mins after application of NaHS. Bar graphs showed average of the peak current densities of ITotal (C), IA (D) and IK (E) currents. The current density (in pA/pF) was calculated by dividing the peak current amplitude by cell membrane capacitance. NaHS application caused a significant reduction of IK. Current subtraction revealed that NaHS application did not alter the IA density. *p<0.05, compared with that of PRE.

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