Figure 5From: Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neuronsReduction in escape threshold by NaHS injection. NaHS, a donor of H2S, produced mechanical hyperalgesia in a dose-dependent manner when applied subcutaneously. Concentrations of NaHS used were 50 (A), 250 (B) and 1000 (C) μM in a volume of 50 μL. The maximal effect was observed at a dose of 1000 μM. The longest duration was 1.5 hours at concentration of 1000 μM. Normal saline (NS) at the same volume was used as control. NS did not produce any effect on escape threshold (D). *p<0.05, compared with NS.Back to article page