Figure 4

Drug effects on anxiety-like behavior and locomotion. Open-arm choice in the elevated plus maze (EPM) was measured for 5 min as the ratio of open-arm entries to the total number of entries expressed as % in sham controls (A) and arthritic animals (B). The combination of intra-BLA SB242084 (10 μM) and systemic fluvoxamine (30 mg/kg) had no effect in sham controls but increased the open-arm choice of arthritic rats significantly. *P < 0.05, compared to vehicle, one-way ANOVA followed by Dunnett’s multiple comparison tests). (C) Evaluation of locomotor activity (total number of entries into the 4 arms of the EPM) in sham controls (left bar) and arthritic animals for 30 min. Locomotor activity was decreased in arthritic rats. The different drug regimen tested in arthritic rats had no effect. Bar histograms show means ± SEM.