Figure 5From: 5-HT2CR blockade in the amygdala conveys analgesic efficacy to SSRIs in a rat model of arthritis painDrug effects on hindlimb withdrawal thresholds. Reflex thresholds were measured in sham controls (A) and arthritic rats (B) using a calibrated forceps for mechanical compression of the knee joint. Intra-BLA application of SB242084 (10 μM), systemic administration of fluvoxamine (30 mg/kg, i.p), and combined administration of SB242084 and fluvoxamine had no effect on reflex thresholds in control or arthritic rats. Bar histograms show means ± SEM.Back to article page