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Table 1 Staining density for IL-6, IL6R, and gp130 mRNA

From: Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain

Mean density (D ± SD)

Animals

Ganglia and time

IL-6

IL-6R

Gp130

Naïve

L-DRGn

0.053 ± 0.006

0.170 ± 0.050

0.320 ± 0.121

C-DRGn

0.042 ± 0.006

0.142 ± 0.042

0.440 ± 0.755

Operated

3D L-DRGi

0.386 ± 0.139*

0.434 ± 0.111*

0.540 ± 0.090

3D L-DRGc

0.427 ± 0.064*

0.405 ± 0.119*

0.450 ± 0.047

3D C-DRGn

0.464 ± 0.069*

0.518 ± 0.119*

0.490 ± 0.394

14D L-DRGi

0.536 ± 0.070*

0.273 ± 0.065*

0.470 ± 0.192

14D L-DRGc

0.419 ± 0.132*

0.165 ± 0.030

0.250 ± 0.182

14D C-DRGn

0.332 ± 0.079*

0.201 ± 0.046

0.440 ± 0.154

Sham-operated

3D L-DRGi

0.045 ± 0.006

0.241 ± 0.053

0.370 ± 0.276

3D L-DRGc

0.062 ± 0.006

0.232 ± 0.030

0.270 ± 0.089

3D C-DRGn

0.056 ± 0.006

0.207 ± 0.062

0.320 ± 0.459

14D L-DRGi

0.075 ± 0.010

0.208 ± 0.033

0.290 ± 0.544

14D L-DRGc

0.074 ± 0.007

0.159 ± 0.015

0.340 ± 0.058

 

14D C-DRGn

0.085 ± 0.005

0.210 ± 0.040

0.490 ± 0.309

  1. * Statistical significance (p < 0.05) when compared with naïve DRG.
  2. Results of staining density for mRNA in lumbar ipsilateral (L-DRGi), lumbar contralateral (L-DRGc), and cervical (C-DRGn) dorsal root ganglia removed from naïve (Naïve), CCI- and sham-operated rats for 3 and 14 d of survival (3D, 14D).
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Molecular Pain

ISSN: 1744-8069

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