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Figure 5 | Molecular Pain

Figure 5

From: Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat

Figure 5

Examples of ratemater records which illustrate the effect of intra-VL PAG microinjection of MMPIP (5 μg/ 0.2μl) on either the ongoing or tail flick-related burst of activity of identified RVM ON cells (A and B) and ongoing or tail flick-related pause of identified RVM OFF cells (C and D) in sham and SNI rats. Intra-VL PAG microinjection of MMPIP (5 μg/0.2μl) did not change the ongoing activity and the tail flick-related burst of the ON cell in sham rats (A) but reduced them in SNI rats (B). The same treatment did not modified the OFF cell activity in the sham rats (C) but increased the ongoing activity and reduced the tail flick-related pause of the OFF cell in SNI rats (D). Scales bars indicate 5 min and small full arrows indicate the noxious stimulation application.

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Molecular Pain

ISSN: 1744-8069

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