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Figure 1 | Molecular Pain

Figure 1

From: Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors

Figure 1

Schematic representation of the facilitation of KOR/MOR heterodimerization by E2. Biochemical and behavioral experiments suggest that ERs work cooperatively to increase KOR/MOR expression. We postulate that E2 triggers a signaling complex containing one or multiple ERs, which via an unknown mechanism enhances the formation of KOR/MOR heterodimers and thereby creates the sex difference in opioid actions. Modified from [131].

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Molecular Pain

ISSN: 1744-8069

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