Table 1 Tissue distribution and subcellular localization of PP2A subunits
From: Roles of phosphotase 2A in nociceptive signal processing
Subunits | Molecule | KDa | Isoforms | Tissue distribution | Subcellular localization |
|---|---|---|---|---|---|
Structure subunit | A | 65 | α and β | Ubiquitously expressed | |
Catalytic subunit | C | 36 | α and β | Ubiquitously expressed. High levels in brain and heart. | |
Regulatory subunit | B | 55 | B α | Wide-spread tissue distribution | Cytosolic fraction |
B β | Enriched in brain | Cytosolic fraction | |||
B δ | Wide-spread tissue distribution | ||||
B γ | Enriched in brain | Cytoskeletal fraction | |||
B’ α | Widely expressed and abundant in heart and skeletal muscle | Cytoplasma | |||
B’ β | Enriched in brain | Cytoplasma | |||
B’ δ | Enriched in brain | Neucleus and cytoplasma | |||
B’ γ | Widely expressed and abundant in heart and skeletal muscle | Neucleus | |||
B’ ϵ | Cytoplasma | ||||
B” PR72 | Heart and skeletal muscle | ||||
B”PR130 | Ubiquitously expressed and high levels in heart and muscle | ||||
B”PR59 | Testis, kidney, liver, brain, heart and lung | ||||
B”PR48 | neucleus | ||||
B”’ PR93 | neucleus | ||||
B”’PR110 | Postsynaptic densities of neuronal dendrites |