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Figure 1 | Molecular Pain

Figure 1

From: Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by Granulocyte-/Granulocyte-macrophage colony stimulating factors

Figure 1

GMCSF- or GCSF- mediated gene pool in the peripheral sensory neurons. (A) Heat map representation of significantly-regulated transcripts showing more than two-fold change (two-tailed t-test assuming equal variance, P with Benjamini and Hochberg False Discovery Rate correction <0.05) following chronic exposure to GMCSF or GCSF in sensory neurons of the DRG. The color scale represents quantile normalized hybridization intensities for each gene. (B) Venn diagram representing the number of genes commonly or differentially regulated by GMCSF and GCSF exposure in DRG neurons. (C) Selected pain-related genes that were significantly regulated (two-tailed t-test assuming equal variance, P with Benjamini and Hochberg False Discovery Rate correction <0.05). Genes commonly (green text) or differently (red text) regulated by GMCSF and GCSF stimulation in sensory neurons are shown. Gene regulation confirmed by qRT-PCR analysis is highlighted in bold text.

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