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Figure 5 | Molecular Pain

Figure 5

From: Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by Granulocyte-/Granulocyte-macrophage colony stimulating factors

Figure 5

QRTPCR-based validation of GM-CSF-induced regulation of the expression of Rac1, MMP9, Calpain2 and TNFα in vitro as well as in vivo . Gene regulation at 24 h following the start of GMCSF exposure in cultured sensory neurons is shown in (A) and in DRGs at different time points following intraplantar GMCSF injection is shown in (B). * denotes P ≤ 0.05 as compared to vehicle group, One-Way ANOVA followed by Fisher’s LSD Post-hoc analysis, n = 3 mice per group. (C) Schematic representation of the protocol followed to investigate changes in GMCSF-mediated mechanical and thermal hypersensitivity upon inhibition of Rac1 or MMP9 or Calpain 2 or TNFα in vivo.

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Molecular Pain

ISSN: 1744-8069

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