Skip to main content
Figure 6 | Molecular Pain

Figure 6

From: Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by Granulocyte-/Granulocyte-macrophage colony stimulating factors

Figure 6

In vivo validation of GM-CSF transcriptional targets in DRG neurons in the context of nociceptive sensitization evoked by long-term exposure to GMCSF. Changes in GMCSF-mediated mechanical hypersensitivity upon inhibition of Rac1 (A), MMP9 (C), Calpain-2 (E) or TNFα (G) as compared to corresponding vehicle-treated mice are shown. Response frequency to the von Frey filament at 0.16 g force is represented on the Y-axis. Changes in GM-CSF-mediated thermal hypersensitivity upon inhibition Rac1 (B), MMP9 (D), Calpain-2 (F) or TNFα (H) as compared to corresponding vehicle-treated mice are shown. Withdrawal latency in seconds to calibrated radiant heat is represented on the Y-axis. * denotes P ≤ 0.05 as compared to basal values, † denotes P ≤ 0.05 relative to corresponding vehicle treated group, One-Way ANOVA with repeated measures followed Fisher’s LSD Post-hoc analysis , n = 6 mice per group.

Back to article page