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Figure 2 | Molecular Pain

Figure 2

From: Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation

Figure 2

Schematic drawing of double labeling of TRG neurons and an example of FG/MB-labeled TRG neurons. A: TRG neurons innervating the masetter muscle (MM) were labeled by fluorogold (FG) and the same neurons projecting to the trigeminal subnucleus interpolaris/caudalis transition region (Vi/Vc) were labeled by fluorescent latex microbeads (MB). Inset show the location of MB injection sites. AP, area postrema; NTS nucleus of tractus solitaries; Cu, cunate nucleus, LRN, Lateral reticular nucleus; Pyt, pyramidal tract. B-C : TRG neurons that innervated masseter muscle (MM) (B) projected onto the Vi/Vc region (C) in naïve rats. E-F: TRG neurons that innervated masseter muscle (MM) (E) projected onto the Vi/Vc region (F) in inflamed rats. B,E : Fluorescence micrograph showing FG-labeled TRG neurons. C,F : MB-labeled TRG neurons in the same section. D and G: Merge. Triangle shows an example of FG/MB-labeled TRG neurons. Bar = 20 μm.

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Molecular Pain

ISSN: 1744-8069

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