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Figure 5 | Molecular Pain

Figure 5

From: Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation

Figure 5

Effect of BDNF on the neuronal excitability of small-diameter FG/MB-labeled TRG neurons in naïve and inflamed rats. A : BDNF (50 ng/ml) induced neuronal depolarization with spike discharges in FG/MB labeled TRG neurons in naïve rats. The break in the trace is 5 min. B : BDNF(10 ng/ml) induced strong neuronal depolarization with spike discharges in small-diameter FG/MB labeled TRG neurons in inflamed rats. The break in the trace is 13 min. C : Spontaneous discharge in small-diameter FG/MB labeled TRG neurons in inflamed rats. The percentage and mean firing frequency of TRG exhibiting spontaneous discharges increased following inflammation. The break in the trace is 7 min. D : The threshold concentration of BDNF required for spike generation depolarization in inflamed rats was significantly lower than in naïve rats. E : Dose–response relationship for BDNF-induced depolarization in naïve and inflamed rats. (n = 4, #, p < 0.05, 1 vs 10, 50 and 100 ng/ml, *, p < 0.05, naïve vs inflamed). F : Comparison of discharge frequency induced by BDNF (50 ng/ml) in naïve and inflamed rats. *P < 0.05.

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Molecular Pain

ISSN: 1744-8069

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