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Figure 6 | Molecular Pain

Figure 6

From: Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation

Figure 6

Comparison of effect of BDNF on the firing frequency of small-diameter FG/MB-labeled TRG neurons from naïve and inflamed rats. A : Wave form of action potential in response to depolarizing current pulses. Note the prominent shoulder on the falling phase (triangle). B : Action potential induced at threshold level (300 ms, 100 pA) which was resistant to TTX (1 μM). C : Action potential firing rate during depolarization of step pulse before (upper trace) and after (middle trace) BDNF (50 ng/ml), and after BDNF (50 ng/ml) + K252a (10 ng/ml; lower trace) application to small-medium diameter TRG neurons in naïve and inflamed rats. D : Threshold current for spike generation during current injection before and after BDNF and after BDNF + K252a applications; P < 0.05. E : Number of spike discharges during current injection before and after BDNF and after BDNF + K252a applications; P < 0.05. F : The relative number of spikes during current injection (100 pA, 200 ms) was significantly higher in inflamed rats than in naïve rats. *P < 0.05.

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