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Table 1 Mechanical hypersensitivity following intraplantar injection of 0.25-1 μg/paw capsaicin in WT mice and hph mice

From: Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

Time of testing (min)     
Concentration von Frey (g) Baseline 30 60
0.25 μg/paw     
WT mice 0.81±0.04 1.00±0.00 0.49±0.15b 0.39±0.07b
hph mice 0.78±0.04a 1.00±0.00 0.44±0.10a,b 0.47±0.07a,b
0.5 μg/paw     
WT mice 0.81±0.08 1.00±0.00 0.26±0.03b 0.28±0.11b
hph mice 0.80±0.10a 1.00±0.00 0.28±0.11a,b 0.26±0.03a,b
1 μg/paw     
WT mice 1.03 ± 0.09 1.00±0.00 0.18±0.04b 0.19±0.03b
hph mice 0.99 ± 0.04a 1.00±0.00 0.42±0.10b,c 0.39±0.07b,c
  1. The results are expressed as relative pain behaviour (normalised to the baseline response of each mouse). For 0.25, 0.5 and 1 μg/paw n = 3–6, n = 4 and n = 6–10, respectively. The letter a, indicates non-significant differences when compared to WT mice (p > 0.05), the letter b, indicates significant differences compared to baseline, and the letter c, indicates significant differences relative to WT (p < 0.05). Unpaired t-test (two-tailed) or two-way RM-ANOVA with Fisher’s LSD test. Data is shown as mean ± SEM.