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Table 1 Mechanical hypersensitivity following intraplantar injection of 0.25-1 μg/paw capsaicin in WT mice and hph mice

From: Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

Time of testing (min)

    

Concentration

von Frey (g)

Baseline

30

60

0.25 μg/paw

    

WT mice

0.81±0.04

1.00±0.00

0.49±0.15b

0.39±0.07b

hph mice

0.78±0.04a

1.00±0.00

0.44±0.10a,b

0.47±0.07a,b

0.5 μg/paw

    

WT mice

0.81±0.08

1.00±0.00

0.26±0.03b

0.28±0.11b

hph mice

0.80±0.10a

1.00±0.00

0.28±0.11a,b

0.26±0.03a,b

1 μg/paw

    

WT mice

1.03 ± 0.09

1.00±0.00

0.18±0.04b

0.19±0.03b

hph mice

0.99 ± 0.04a

1.00±0.00

0.42±0.10b,c

0.39±0.07b,c

  1. The results are expressed as relative pain behaviour (normalised to the baseline response of each mouse). For 0.25, 0.5 and 1 μg/paw n = 3–6, n = 4 and n = 6–10, respectively. The letter a, indicates non-significant differences when compared to WT mice (p > 0.05), the letter b, indicates significant differences compared to baseline, and the letter c, indicates significant differences relative to WT (p < 0.05). Unpaired t-test (two-tailed) or two-way RM-ANOVA with Fisher’s LSD test. Data is shown as mean ± SEM.
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Molecular Pain

ISSN: 1744-8069

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