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Figure 10 | Molecular Pain

Figure 10

From: Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Figure 10

Suppression effect of CCI-779 on BmK I-induced rat pain behaviors. (A) Rat flinch behavior was attenuated when rats were pre-treated with CCI-779 (250 μM) 30 min before BmK I administration. Suppression of total number of the rat paw flinches (B) and total number of paroxysmal pain-like behaviors (C) by CCI-779 during 2 h after BmK I injection. (D) No effects on lifting and licking behaviors. Suppression on ipsilateral (E) and contralateral (F) mechanical, and ipsilateral thermal (G) hypersensitivity by CCI-779, but no effect on contralateral basal thermal threshold value (H). *p<0.05, **p<0.01, ***p<0.001, compared with BmK I group. #p<0.05, ##p<0.01, ###p<0.001, compared with vehicle group. n=8 for each group.

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Molecular Pain

ISSN: 1744-8069

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