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Figure 11 | Molecular Pain

Figure 11

From: Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Figure 11

Post-treatment with rapamycin suppressed unilateral thermal hypersensitivity and bilateral mechanical hypersensitivity induced by intraplantar BmK I injection. (A and B) showed the suppressive effects on BmK I-induced the ipsilateral (A) and contralateral (B) mechanical hypersensitivity by different doses of rapamycin post-treatment (20 μM, 200 μM and 2 mM). (C and D) showed that different doses of rapamycin post-treatment (20 μM, 200 μM and 2 mM) suppressed ipsilateral (C) thermal hypersensitivity but did not affect the contralateral basal thermal threshold value (D). **P<0.01, ***P<0.001, compared with relevant control groups treated with DMSO. n=8 for each group.

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Molecular Pain

ISSN: 1744-8069

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