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Figure 8 | Molecular Pain

Figure 8

From: Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Figure 8

Suppression effect of rapamycin on BmK I-induced rat pain behaviors. (A) Rat flinch behavior was attenuated when rats were pre-treated with rapamycin (20 μM, 200 μM and 2 mM) 30 min before BmK I administration. Suppression of total number of the rat paw flinches (B) and total number of paroxysmal pain-like behaviors (C) by rapamycin (20 μM, 200 μM and 2 mM) during 2 h after BmK I injection. Suppression effect on ipsilateral (E) and contralateral (F) mechanical hypersensitivity, and ipsilateral (G) thermal hypersensitivity by different doses of rapamycin pre-treatment (20 μM, 200 μM and 2 mM). However, rapamycin did NOT affect the lifting and licking behaviors (D) and the contralateral basal thermal threshold value (H). *p<0.05, **p<0.01, ***p<0.001, compared with BmK I group; #p<0.05, ##p<0.01, ###p<0.001, compared with DMSO vehicle group. n=8 for each group.

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Molecular Pain

ISSN: 1744-8069

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