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Table 1 The No. of rat flinch behavior in respective groups

From: Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

 

BmK I

BmK I+25%DMSO

BmK I+20 μM RAPA

BmK I+200 μM RAPA

BmK I+2 mM RAPA

5 min

62.8±6.0

61.4±5.3

49.8±2.8

52.6±4.8

48.9±3.7

10 min

59.7±3.6

65.6±7.2

41.8±3.0 #

37.0±4.0 *, ##

44.8±5.2 #

15 min

59.3±3.6

62.1±5.7

39.0±5.0 #

43.9±6.6

39.9±5.8

20 min

58.6±5.0

64.9±6.1

35.8±4.0 **, ##

37.3±5.2 *, ##

39.5±3.7 *, ##

25 min

65.1±6.1

63.5±6.0

39.1±5.2 **, #

44.3±5.0

38.4±4.5 **, #

30 min

62.3±6.9

67.4±5.5

39.9±5.1

39.1±2.8 #

42.4±7.4 #

35 min

63.0±4.4

68.9±4.8

35.1±3.5 ***, ###

41.0±1.5 *, ###

38.6±6.2 **, ###

40 min

67.7±7.0

70.8±3.3

37.9±2.2 **, ###

38.0±4.0 **, ###

44.8±5.8 *, ##

45 min

61.6±6.2

69.9±5.0

38.9±2.4 **, ###

32.1±3.1 ***, ###

37.6±5.4 **, ###

50 min

70.9±6.7

66.8±6.1

37.1±3.1 **, ##

31.1±4.8 ***, ###

41.9±6.7 *, #

55 min

62.7±5.7

65.5±4.7

38.3±4.4 **, ##

33.3±6.1 ***, ###

40.8±3.0 *, #

60 min

63.1±6.3

56.0±6.3

43.5±1.8

29.4±4.6 ***, ##

44.0±4.3

65 min

57.0±7.2

47.4±3.6

43.3±2.8

26.3±4.8 **, #

39.6±5.1

70 min

53.4±2.8

47.8±3.9

39.1±4.3

31.8±3.7 *

32.3±5.2 *

75 min

45.0±2.0

52.1±4.5

37.6±4.0

29.9±3.5 *, ###

31.4±2.8 *, ##

80 min

50.0±6.2

51.6±6.3

38.4±5.4

31.0±5.2 **, ###

38.0±3.2

85 min

49.3±4.5

48.0±4.7

36.8±1.8 #

23.9±3.0 **, ###

33.8±3.8 #

90 min

48.9±5.2

55.0±4.6

33.5±4.0

22.1±5.0

33.9±4.2

95 min

46.4±1.8

40.6±5.9

37.5±5.0

26.0±5.3

29.3±4.8 *

100 min

43.4±5.3

42.1±7.0

36.6±3.5

29.0±3.0

24.3±4.2

105 min

39.0±2.7

40.0±6.9

31.8±3.5

28.1±4.0

31.6±6.3

110 min

31.7±4.4

36.1±5.5

31.8±2.6

24.6±2.7

27.1±5.4

115 min

26.6±2.8

37.6±5.3

29.5±3.3

30.6±3.4

24.8±5.2

120 min

30.1±5.6

33.5±6.3

29.8±3.8

21.8±3.9

21.1±5.2

Total

1258.8±76.7

1314.63±72.71

896.63 ± 44.46 **, ###

784.00 ± 48.79 ***, ###

868.38 ± 68.76 **,###

  1. Note: *p<0.05, **p<0.01, ***p<0.001, compared with BmK I group. #p<0.05, ##p<0.01, ###p<0.001, compared with DMSO group.
  2. One-way ANOVA followed by a Bonferroni's post hoc test.