Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Table 2 Effect of rapamycin (pre-treatment) on mechanical and thermal hypersensitivity induced by BmK I

	Paw withdrawal mechanical threshold (g)					Paw withdrawal thermal latency (s)
	Naive	Vehicle	Rapa	Rapa	Rapa	Naive	Vehicle	Rapa	Rapa	Rapa
	Naive	Vehicle	20 μM	200 μM	2 mM	Naive	Vehicle	20 μM	200 μM	2 mM
Ipsilateral
Base line	26.00 ± 0.00	26.00 ± 0.00	26.00 ± 0.00	26.00 ± 0.00	24.63 ± 1.38	12.74 ± 0.32	13.28 ± 0.38	12.60 ± 0.27	12.26 ± 0.24	12.66 ± 0.37
4 h	2.625 ± 0.42	1.80 ± 0.32	4.25 ± 0.45	7.75 ± 0.80 ***, ###	10.25 ± 1.08 ***, ###	6.84 ± 0.26	6.38 ± 0.32	8.01 ± 0.27 #	10.13 ± 0.23 ***, ###	11.24 ± 0.51 ***, ###
8 h	2.18 ± 0.27	1.8 ± 0.32	6.75 ± 0.53 ***, ###	8.5 ± 0.82 ***, ###	11.38 ± 2.35 ***, ###	6.62 ± 0.23	6.69 ± 0.29	9.39 ± 0.39 ***, ###	11.48 ± 0.55 ***, ###	12.06 ± 0.48 ***, ###
Contralateral
Base line	26.00 ± 0.00	26.00 ± 0.00	26.00 ± 0.00	26.00 ± 0.00	24.63 ± 1.38	12.10 ± 0.43	12.43 ± 0.26	13.09 ± 0.26	11.99 ± 0.23	13.28 ± 0.49
4 h	3.75 ± 0.70	2.25 ± 0.25	7 ± 0.53	15.63 ± 3.17 ***, ###	17.25 ± 3.38 ***, ###	12.9 ± 0.20	11.58 ± 0.23	12.26 ± 0.24	12.71 ± 0.37	12.69 ± 0.49
8 h	3.68 ± 0.50	2.50 ± 0.50	10.50 ± 1.10 *, ##	13.63 ± 2.03 ***, ###	17.88 ± 3.20 ***, ###	12.28 ± 0.33	11.78 ± 0.28	12.04 ± 0.29	12.79 ± 0.12	12.50 ± 0.23

Note: *p<0.05, **p<0.01, ***p<0.001, compared with BmK I group; #p<0.05, ##p<0.01, ###p<0.001, compared with vehicle group. Two-way ANOVA followed by a Bonferroni's post hoc test.

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