Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Table 3 Effect of CCI-779 (pre-treatment) on mechanical and thermal hypersensitivity induced by BmK I

	Paw withdrawal mechanical threshold (g)			Paw withdrawal thermal latency (s)
	Naïve	Vehicle	CCI-779	Naïve	Vehicle	CCI-779
Ipsilateral
Base line	26.00 ± 0.00	26.00 ± 0.00	26.00 ± 0.00	12.74 ± 0.40	13.64 ± 0.23	13.55 ± 0.44
4 h	2.63 ± 0.42	1.88 ± 0.36	6.50 ± 0.73 ***, ###	6.84 ± 0.35	7.75 ± 0.26	9.64 ± 0.35 ***, ###
8 h	2.18 ± 0.27	3.25 ± 0.62	8.88 ± 1.16 ***, ###	6.62 ± 0.28	7.43 ± 0.30	10.99 ± 0.37 ***, ###
Contralateral
Base line	26.00 ± 0.00	26.00 ± 0.00	24.63 ± 1.38	12.10 ± 0.50	13.28 ± 0.37	13.69 ± 0.44
4 h	3.75 ± 0.70	2.35 ± 0.37	12.00 ± 1.17 ***, ###	12.90 ± 0.27	13.71 ± 0.39	12.95 ± 0.61
8 h	3.68 ± 0.50	4.25 ± 0.70	17.63 ± 2.61 ***, ###	12.28 ± 0.45	13.36 ± 0.53	12.61 ± 0.35

Note: ***p<0.001, compared with BmK I group; ###p<0.001, compared with cehicle group. Two-way ANOVA, Bonferroni's post hoc test.

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