Figure 1
Inhibition of VGCCs in DRG neurons by ω-conotoxins. A. Current–voltage (I-V) curve showing the block of high-voltage activated ICa by 300 nM CVID. Inset, representative recording of ICa, with the current trace following block by CVID shown in green. B. Time-plot of inhibition of HVA ICa by specific blockers for different calcium channel subtypes, i.e. CVID for N-, ω-agatoxin IVA for P/Q-, nimodipine for L-, SNX-482 and CdCl2 for ICa resistant (res.) to all other blockers . Inset, proportions of the different subtypes shown as percentages present in mouse DRG neurons. C. Representative recordings of ICa showing block by ω-conotoxins CVIE and CVIF. D. Concentration-response curves for each ω-conotoxin.