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Table 2 Effects of the three ω-conotoxins on motor coordination tested on an accelerating rotarod and grip strength test using a grip strength meter

From: Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration

Treatment/test

Rotarod performance

Grip strength

 

Time to fall (s)

End rate (rpm)

Peak tension (g)

Tension/weight

Vehicle (n = 9)

39 ± 4.2

18 ± 1.4

130 ± 5.5

5.8 ± 0.3

CVID (n = 7)

40 ± 4.1

18 ± 1.4

121 ± 5.7

5.7 ± 0.3

CVIE (n = 7)

36 ± 4.1

17 ± 1.4

121 ± 6.9

5.5 ± 0.3

CVIF (n = 7)

36 ± 3.0

17 ± 1.0

121 ± 7.7

5.4 ± 0.4

  1. All ω-conotoxins were tested in naïve mice at the maximal analgesic dose (2 mg/kg, s.c.) at the time of maximal analgesic effect (2 h). None of the ω-conotoxins produced any significant effect on ability of mice to perform on the rotarod or maintain grip strength (each parameter tested by one-factor ANOVA; all P > 0.6).
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Molecular Pain

ISSN: 1744-8069

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