Figure 1

Decrease of mechanical and cold nociceptive threshold induced by oxaliplatin. Each mouse received two intravenous injections per week for 4,5 weeks, totalizing nine injections. Withdrawal responses were determined once a week until the 49th day. Panel A: paw withdrawal threshold of control (C, vehicle, n = 12) and treated (oxaliplatin 1 mg/kg, 2 mg/kg and 4 mg/kg, n = 12) mice to the electronic pressure meter (electronic von Frey) applied to the plantar surface of the hind paw. Panel B: Tail withdrawal threshold of Control (C, vehicle, n = 12) and treated (oxaliplatin 1 mg/kg, 2 mg/kg and 4 mg/kg, n = 12) mice to tail immersion in cold non-noxious (10°C) water. The results are reported as the means ± SEM paw withdrawal threshold (g) for mechanical threshold (panel A) and tail withdrawal response (s) for the cold threshold (panel B). A significant reduction in mechanical and thermal threshold (***p < 0.001, ANOVA followed by Student Newman-Keuls post hoc test), was observed when compared with the vehicle group.