Figure 3

Antinociceptive effects of rutin and quercetin on cold nociceptive threshold in oxaliplatin (OXL)-treated mice (tail immersion). The mice received two intravenous injections of OXL (1 mg/kg) per week for 4.5 weeks for a total of nine OXL injections. Rutin (A) and quercetin (B) were injected intraperitoneally 30 min before every OXL administration. The control group received saline instead of rutin or quercetin. The thermal test (tail immersion test in cold water, 10°C) was conducted before and every 7 days after each treatment. The data points represent the mean ± SEM of the reaction time in seconds after tail immersion in cold water in six animals.*p < 0.05, **p < 0.01, ***p < 0.001 (ANOVA followed by Student Newman-Keulspost hoc test).