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Figure 9 | Molecular Pain

Figure 9

From: The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy

Figure 9

iNOS immunostaining in the dorsal horn of the spinal cord of mice subjected to oxaliplatin (OXL)-induced neurotoxicity and treated with rutin or quercetin. The mice received two intravenous injections of OXL (1 mg/kg) per week for 4.5 weeks for a total of nine OXL injections. Rutin or quercetin (50 mg/kg) were injected intraperitoneally 30 min before OXL administration. The control group received saline instead of rutin and quercetin. (A) Naive animals; (B) Oxaliplatin plus saline; (C) Oxaliplatin plus rutin (50 mg/kg); (D) Oxaliplatin plus quercetin (50 mg/kg). 400× magnification. (E) Bars show the percentage of positive iNOS staining area, mean ± SEM (n = 4). **p < 0.01, compared with saline plus oxaliplatin-treated group (S); ##p < 0.01, compared with naive (C) group (ANOVA followed by Student Newman-Keuls post hoc test).

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Molecular Pain

ISSN: 1744-8069

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