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Figure 1 | Molecular Pain

Figure 1

From: Gq rather than G11 preferentially mediates nociceptor sensitization

Figure 1

Behavioral responses to intraplantar GPCR-ligands in control mice (black square symbols), G 11 -/-mice (green triangle symbols), SNS-G q/11 -/-mice (red circular symbols) and SNS-G q -/-mice (blue cross symbols). Magnitude and time course of hyperalgesia to plantar heat following unilateral intraplantar hindpaw injection of Glutamate (A; n= 9 for control, SNS-Gq-/- and SNS-Gq/11-/- mice and n= 8 for G11-/- mice) S1P (B; n= 8 for all groups) and Thrombin (C; n= 8 for both groups) and of mechanical allodynia to mechanical von Frey filament stimulation following unilateral injection of Serotonin (D; n= 8 for control, G11-/- and SNS-Gq/11-/- mice and n= 7 for SNS-Gq-/- mice), mcPAF (E; n= 8 for G11-/- and SNS-Gq-/- mice and n= 7 for control and SNS-Gq/11-/- mice) Endothelin (F; n= 8 for control and SNS-Gq/11-/- mice and n= 7 for G11-/- and SNS-Gq-/- mice). * P<0.05 as compared to the control group, as compared to basal values within a group, ANOVA, post hoc Bonferroni’s test. All data points represent mean ± SEM.

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