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Figure 1 | Molecular Pain

Figure 1

From: Erratum to: Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats

Figure 1

MMP-2/9 inhibitor administration altered the protein levels of NGF and MMP-9 in the skin of naive rats. Western blot analysis performed on the glabrous skin samples following 14 days of repeated MMP-2/9 inhibitor (MMP-2/9I.; 20 μg, i.pl.) administration showed a significant increase in the protein levels of mature NGF (mNGF) (A), with no influence on the protein level of the precursor proNGF (B). Repeated administration of MMP-2/9I. (20 μg, i.pl.) significantly reduced the protein levels of MMP-9 (C) in the glabrous skin. Examples of representative western blots are presented in the upper panels A, B and C. The densitometry results are presented as the mean ± SEM from all samples. Inter-group differences were analyzed by ANOVA with a Bonferroni’s multiple comparison test. ***p < 0.001 indicates a significant difference as compared to glabrous skin sample of chronic vehicle-treated (V) naive rats. The interrupted line on the graphs indicates protein analyses for mNGF, proNGF or MMP-9 in the contralateral glabrous skin of chronic MMP-2/9I.-treated naïve rats.

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