Figure 4

Correlation of inflammatory mediator expression between day 3 and 14 in each femorotibial tissue. Day 3 and day 14 gene expression was plotted against each other for the cartilage (A), fat pad (B) and subchondral bone (C). For each tissue there was a positive and significant correlation (A-C, r = 0.227 p = 0.00743, r = 0.327 p = 0.00147, r = 0.283 p = 0.00629, respectively). By expressing the data this way, those factors which had a > 2 fold increase at both time points could be identified (red shaded area). In total there were 11 of these genes in the cartilage (A), 3 in the fat pad (B) and 4 in the subchondral bone (C). Pearson’s correlation coefficient, n = 92. Data is displayed as the mean FC, FC = MIA/Control. Both axes on Log 2 scale.