Table 1 DAY 3: Top up-regulated inflammatory mediators in the MIA model
Rank | Cartilage | Subchondral bone | Fat pad | |||
|---|---|---|---|---|---|---|
| Â | Gene name | FC | Gene name | FC | Gene name | FC |
1 | CCL21 | 20.8 (4.0-108.2) | CCL17 | 5.7* (4.5-7.3) | EREG | 10.1 (2.8-36.3) |
2 | IL12B | 13.9 (3.7-51.9) | IL12b | 5.4 (2.3-12.8) | NRG1 | 7.4 (2.6-20.9) |
3 | CCL12 | 13.9* (6.0-31.9) | BDNF | 4.8 (1.8-13.1) | AREG | 7.0* (3.8-13.2) |
4 | EREG | 8.3 (2.6-25.7) | CCL7 | 4.7 (2.6-8.4) | iNOS | 5.0* (2.9-8.8) |
5 | CCL2 | 5.8 (2.7-12.6) | CXCL11 | 4.3 (1.4-13.1) | CXCL5 | 4.9* (3.2-7.6) |
6 | CCL7 | 5.8 (2.8-11.7) | IL6 | 3.5 (1.0-12.0) | GCSF | 4.1 (1.7-10.1) |
7 | CXCL1 | 4.9 (2.3-10.2) | CCL2 | 2.9 (1.7-5.0) | IL11 | 3.8 (2.2-6.4) |
8 | XCL1 | 4.4** (3.8-5.1) | CCL5 | 2.6 (1.6-4.2) | CCL3 | 2.3 (-1.3-7.2) |
9 | CCL5 | 3.9* (2.9-5.4) | EDN1 | 2.5 (1.2-4.9) | ARTN | 2.3 (1.6-3.3) |
10 | CXCL13 | 3.7 (1.3-10.3) | ARTN | 2.4 (1.4-4.4) | LIF | 2.1 (1.4-3.1) |
11 | IBA1 | 3.6* (2.8-4.6) | CCL9 | 2.4* (1.9-3.0) | NGF | 1.9 (1.4-2.5) |
12 | CXCL2 | 3.5 (-1.3-15.1) | CCL21 | 2.3 (-4.9-26.2) | CXCL17 | 1.9 (-1.5-5.4) |