Table 2 DAY 14: Top up-regulated inflammatory mediators in the MIA model
Rank | Cartilage | Subchondral bone | Fat pad | |||
|---|---|---|---|---|---|---|
| Â | Gene name | FC | Gene name | FC | Gene name | FC |
1 | CCL7 | 25.5* (12.1-53.8) | CCL9 | 10.8* (7.1-16.5) | BDNF | 26.1 (11.1-61.4) |
2 | CCL2 | 21.8** (12.9-37.0) | CCL7 | 7.2 (1.6-31.6) | iNOS | 10.6 (2.7-40.8) |
3 | CCL9 | 17.0** (12.5-23.0) | CCL22 | 6.3 (3.2-12.6) | CCL1 | 10.1 (2.3-44.0) |
4 | EDN1 | 13.7 (5.1-37.2) | CCL2 | 3.7 (2.2-6.1) | IL3 | 4.0 (1.0-15.7) |
5 | iNOS | 11.4* (8.1-16.2) | LIF | 3.6 (2.7-4.7) | IL27B | 4.0 (2.0-7.8) |
6 | CCL17 | 10.5* (5.1-21.5) | CCL17 | 2.9 (-1.1-9.1) | CCL21 | 3.9 (1.9-8.2) |
7 | AREG | 8.1 (2.7-24.3) | IL11 | 2.6 (1.1-6.5) | AREG | 3.8 (2.6-5.8) |
8 | IL11 | 6.8 (3.7-12.5) | KITLG | 2.2 (1.2-4.1) | CXCL5 | 2.9 (1.6-5.4) |
9 | CXCL13 | 6.6 (2.4-18.3) | iNOS | 1.9 (1.2-3.1) | IL1A | 2.8 (-1.7-12.6) |
10 | PTGES | 5.8** (4.8-7.0) | IL1A | 1.9 (-1.0-3.7) | CCL9 | 2.7 (1.7-42) |
11 | CCL22 | 5.7* (3.4-9.4) | ARTN | 1.8 (1.1-3.0) | NRG1 | 1.9 (-3.3-12.3) |
12 | CCL12 | 5.0 (2.7-9.2) | IL1B | 1.7 (1.1-2.7) | IL7 | 1.8 (-1.4-4.6) |