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Table 3 Top ranked mediators across different comparisons in the MIA model

From: Chemokine expression in peripheral tissues from the Monosodium Iodoacetate model of chronic joint pain

Rank

Greater than 2 FC

Combined ranking

 

Cartilage

Subchondral bone

Fat pad

Day 3

CRV (±SEM)

Day 14

CRV (±SEM)

Day 3 + 14

CRV (±SEM)

1

CCL2

CCL7

iNOS

CCL7

83.0 (5.0)

CCL9

88.3 (2.7)

CCL7

85.0 (3.2)

2

CCL7

CCL17

AREG

CCL5

81.3 (3.2)

iNOS

87.7 (2.0)

CCL2

83.3 (3.8)

3

CCL12

CCL2

CXCL5

CCL2

80.0 (7.0)

CCL7

87.0 (4.5)

CCL9

80.5 (5.3)

4

CCL9

CCL9

-

CCL3

79.0 (2.9)

CCL2

86.7 (3.4)

ARTN

78.2 (2.4)

5

CXCL13

-

-

XCL1

78.3 (4.4)

BDNF

80.7 (5.8)

iNOS

77.8 (6.5)

6

CCL17

-

-

ARTN

78.0 (5.0)

ARTN

78.3 (2.0)

IL18

69.3 (3.9)

7

AREG

-

-

IL6

77.0 (5.8)

IL1A

78.3 (5.2)

AREG

66.2 (12.8)

8

XCL1

-

-

EREG

76.3 (14.2)

CCL22

78.0 (8.3)

XCL1

65.5 (10.6)

9

CXCL2

-

-

CCL21

76.0 (11.0)

CXCL16

72.3 (1.3)

IBA1

65.2 (5.5)

10

IL18

-

-

CCL12

73.3 (11.6)

IL18

72.0 (1.5)

CCL21

64.7 (13.0)

11

ARTN

-

-

PROK2

73.3 (4.2)

CCL4

71.7 (3.2)

CCL4

64.5 (6.9)

12

iNOS

-

-

CCL9

72.7 (8.4)

IL7

71.7 (5.0)

BDNF

63.7 (13.2)

  1. CRV = combined rank value. CCL; chemokine (CC-motif) ligand. AREG; Amphiregulin. XCL; chemokine (XC-motif) ligand IL; Interleukin. CXCL; chemokine (CXC-motif) ligand. ARTN; Artemin. iNOS; inducible nitric oxide. EREG; Epiregulin. PROK2; Prokineticin 2. BDNF; Brain derived neurotrophic factor. IBA1; ionised calcium binding adaptor molecule 1.