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Figure 1 | Molecular Pain

Figure 1

From: N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice

Figure 1

Role of N-type VGCCs in ACC excitatory synaptic transmission in the superficial layer. A, A representative example of MED64 responses before (black) and after (red) ω-Ctx GVIA (1 μM) application. Stimulation (thunderbolt) was given in the deep layer (Ch. 36). The regions are divided into Layer (L) I, II/III and V/VI (vertical lines). Two channels (Ch. 22 and Ch. 38) are selected for further comparison. B, ω-Ctx GVIA (1 μM) was applied for 15 min (filled circle: Ch. 22; open circle: Ch. 38) in a single slice. Sample fEPSP recordings taken at the times indicated by the corresponding numbers are shown above the plot. Calibration: 300 μV, 20 ms. C, Averaged data of 5 activated channels in the superficial layer in one slice. D, Pooled data of 7 mice (45.8 ± 4.4% of baseline, n = 7 slices/7 mice). Application of ω-Ctx GVIA produced an irreversible inhibition of synaptic responses recorded from the superficial layer of the ACC. The horizontal bars indicate the period of drug application. Error bars represent SEM.

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Molecular Pain

ISSN: 1744-8069

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