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Figure 6 | Molecular Pain

Figure 6

From: Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery

Figure 6

hMOR-T and hMOR exhibit similar acute and chronic DAMGO-induced behavioral tolerance. (A) Acute tolerance. On day 1, 4 μg DAMGO produced 88.6% MPE in hMOR rats and, 8 μg DAMGO produced 87.1% MPE in hMOR-T rats. On day 2, similar reduction in DAMGO responses (hMOR: 39.4%, hMOR-T: 44.4%, n = 5-7) were observed. (B) Chronic tolerance was obtained by applying 4 μg/10 μl DAMGO to hMOR and 8 μl/10 μl to hMOR-T twice daily for 4 consecutive days. The rates and extents of DAMGO-induced tolerance developed similarly in hMOR and hMOR-T rat groups.

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Molecular Pain

ISSN: 1744-8069

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