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Figure 5 | Molecular Pain

Figure 5

From: Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA

Figure 5

Analgesic actions of intrathecal ziconotide against noxious thermal and mechanical stimuli in nerve injury model. A, Latency to paw withdrawal from thermal stimulus after intrathecal ziconotide injection (10 pmol) represented as percent maximum possible effect (MPE) for each time point indicated. A, B, Comparison of spinal ziconotide analgesia in response to noxious thermal stimuli in WT (A) and e37b-only (B) mice measured from paws contralateral (C) and ipsilateral (I) to the site of injury. P values at all time points were > 0.05. C, D, Area under the curve of %MPE calculated for each ipsilateral and contralateral paw in response to noxious thermal (C) and mechanical (D) stimuli for WT and e37b mice plotted individually for each animal and connected by a line. Averages are also shown (red). There is a significant decrease in ziconotide efficacy after injury in WT and e37b-only mice (P = 0.017 and 0.002, respectively) whereas there was no difference between genotypes (WT compared to e37b-only P = 0.59 for contralateral and 0.69 for ipsilateral measurements). Student’s two-tailed t-test for all comparisons.

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