Figure 6

Analgesic actions of intrathecal gabapentin against noxious thermal and mechanical stimuli. Latency to paw withdrawal from thermal stimulus after intrathecal gabapentin injection (100 μg) represented as percent maximum possible effect (MPE) for each time point indicated. A, B, Comparison of spinal gabapentin analgesia in response to noxious thermal stimuli in WT (A) and e37b-only (B) mice measured from paws contralateral (C) and ipsilateral (I) to the site of injury. P values at all time points were > 0.05. C, D, Area under the curve of %MPE calculated for each ipsilateral and contralateral paw in response to noxious thermal (C) and mechanical (D) stimuli for WT and e37b mice plotted individually for each animal and connected by a line. Averages are also shown (red). Gabapentin analgesia against noxious mechanical stimuli was slightly but not significantly less effective ipsilateral compared to contralateral to the injured nerve in WT mice (P = 0.11) and less effective ipsilateral compared to contralateral to the injured nerve in e37b-only mice (P = 0.04). Student’s two-tailed t-test.