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Figure 1 | Molecular Pain

Figure 1

From: Involvement of TRPA1 activation in acute pain induced by cadmium in mice

Figure 1

[Ca2+] i increases induced by Cd in a subset of mouse sensory neurons. (A) Cd evokes a [Ca2+]i increase in cultured mouse DRG neurons loaded with fura-2. An image under transmitted light (left), and pseudocolor images (right), before (pre) and after the application of 100 μM Cd (+Cd), and 80 mM KCl (+K). In a bright field image, cells with an arrow (a, b) correspond to (B). (B) Actual recordings of changes in [Ca2+]i responses to Cd and KCl in KCl-responding cells (neurons). (C) Actual recordings of the changes in [Ca2+]i induced by increasing concentrations of Cd (1–300 μM). (D) Circles and columns show the concentration-response curve for Cd-induced [Ca2+]i increases and the percentage of Cd-responding neurons among all neurons, respectively. The percentages of Cd-responding cells were calculated from the percentage obtained with each coverslip. Symbols with vertical lines show mean ± SEM (n=131, from 3 mice).

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