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Figure 3 | Molecular Pain

Figure 3

From: Involvement of TRPA1 activation in acute pain induced by cadmium in mice

Figure 3

Cd-induced [Ca2+] i increase is absent in TRPA1 (−/−) mouse DRG neurons. Actual recordings of [Ca2+]i responses to sequential application of Cd (100 μM, 2 min), cinnamaldehyde (CA, 300 μM, 2 min), capsaicin (Cap, 1 μM, 1 min), and KCl (K, 80 mM, 1 min) in wild-type (A) and TRPA1(−/−) (B) mouse DRG neurons. Venn diagram showing the sensitivities to Cd, cinnamaldehyde, capsaicin and KCl in wild-type (C; n=299 from 5 mice) and in TRPA1(−/−) DRG neurons (D; n=245 from 4 mice). Numerics indicate the number of cells responding to each stimulus. Those in the outermost frames express the number of neurons responding to KCl alone. Note that Cd-responding neurons are mostly coincident with CA-responding ones in the wild-type but they were absent in TRPA1(−/−) mouse DRG neurons.

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