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Figure 5 | Molecular Pain

Figure 5

From: Involvement of TRPA1 activation in acute pain induced by cadmium in mice

Figure 5

Cd-induced [Ca2+] i increases in RIN-14B rat pancreatic cancer cells. (A) Actual traces of [Ca2+]i responses to Cd (30 μM, 4 min) in RIN-14B cells. (B) Effect of removal of extracellular Ca (Ca0) and (C) HC-030031 (10 μM) on the Cd-induced [Ca2+]i increases. Extracellular Ca was removed or a TRPA1 blocker was applied before and during 2 min application of Cd. (D) Summarized effects of these treatments. Columns show the increments of [Ca2+]i in response to Cd. Symbols with vertical lines show mean ± SEM. (Control; n=33, Ca0; n=72, HC-030031; n=34, from 2 experiments) **,P <0.01.

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