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Table 1 Voltage-dependent properties of Ca 2+ channels in DRGs from naive and CFA-treated mice

From: Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels

  Naive CFA
Activation   
Gmax 308 ± 51 288 ± 41
Slope 6.1 ± 0.8 6.5 ± 0.9
V1/2 −25.2 ± 1.0 −25.6 ± 1.0
Inactivation   
Slope 16.5 ± 2.5 9.9 ± 0.9
V1/2 −13.2 ± 4.8 −14.0 ± 1.3
Constitutive Inhibition   
  1.00 ± 0.02 1.01 ± 0.02
GABA B inhibition (%)   
  42.4 ± 3.2 45.5 ± 4.3
  1. Patch-clamp recordings under voltage-clamp conditions were used to examine Ca2+ channel function in medium to large-sized L4-L6 DRG neurons from naive (61± 5 pF) and CFA (64 ± 6 pF) treated mice. CFA did not alter the maximal current amplitude (Gmax; pA/pF; F(13, 234) = 0.21), the kinetics of channel activation (p > 0.05, F(13,126) = 0.04), steady-state inactivation ( p > 0.05, F(12,2040) = 1.3), constitutive current inhibition (p > 0.05, t14 = 0.89) or GABAB inhibition of the Ca2+ channels (p > 0.05, t12 = 0.59). V1/2 = half-maximal potential of the conductance-voltage relationship.