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Figure 1 | Molecular Pain

Figure 1

From: TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity

Figure 1

Mechanical hypersensitivity is prevalent after skin incision with either genetic knockout or pharamacological block of TRPA1. a. Response frequency to 4.5mN filament for WT and TRPA1 KO skin incised and sham mice. Measurements are reported as percent responses (out of 10 total applications of force). Both WT and TRPA1 KO mice exhibit increased mechanical sensitivity on postoperative day 1 (POD1) compared to sham controls (p = 0.0002; **p < 0.01; ***p < 0.0001; represents difference between skin-only and corresponding sham). There is no difference between WT and TRPA1 KO skin-only incised mice at any time point. 10 mice per group. b. Response frequency to 11.2mN filament for WT and TRPA1 KO skin incised and sham mice. Both WT and TRPA1 KO mice exhibit increased mechanical sensitivity at POD1 as compared to sham controls (p < 0.0001; **p < 0.001; ***p < 0.0001; *p < 0.05; represents difference between skin-only and corresponding sham). There is no difference between WT and TRPA1 KO skin-only incised mice at any time point after skin incision. These mice are the same as those used in Figure 1a. c. Response frequencies to 11.2mN filament on POD1 after skin-only incision or sham with treatment with vehicle or TRPA1 antagonist, HC-030031. Skin-only incised mice treated with vehicle as well as those treated with HC-030031 exhibit significantly more responses to the mechanical force than the sham groups (p < 0.0001; **p < 0.001; *p < 0.05). 8 mice per sham group; 12 mice per skin-only incision group.

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