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Figure 3 | Molecular Pain

Figure 3

From: TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity

Figure 3

TRPA1 is not functionally up-regulated in DRG neurons with mixed peripheral targets following skin-only incision injury. a. Percentage of neurons with mixed peripheral targets responding to cinnamaldehyde (CINN). There is no difference in the percentage of neurons responding to 30 or 100 μM CINN between neurons cultures from sham mice and those from skin-only or skin plus deep incised mice. Neurons were pooled from 6 mice per sham and skin-only incision groups and 4 mice in skin plus deep group. b. Amplitude of responses of neurons with mixed peripheral targets to CINN. There is no difference in the amplitude or responses between sham and skin-only neurons to 30 or 100 μM CINN. The amplitude of responses of neurons from skin plus deep incised mice is significantly greater than those from sham and skin-only incised mice (p < 0.0001; **p < 0.01). Same neurons as those in Figure 3a.

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Molecular Pain

ISSN: 1744-8069

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