Figure 6

TRPV1 is functionally up-regulated in IB4-positive, DRG neurons with mixed peripheral targets following skin incision injury. a. Percentage of neurons with mixed peripheral targets responding to capsaicin (CAP). There are significantly more responders to 500nM CAP among ipsilateral lumber 3–5 neurons from skin-only incised WT mice than from sham mice (**p = 0.0052). Neurons pooled from 3 mice per group. b. Amplitude of responses of neurons with mixed peripheral targets to CAP. There is no difference in the amplitude of responses to 500nM CAP between neurons from skin-only incised and sham mice. Same neurons as in Figure 6a. c. Percentage of neurons with mixed peripheral targets responding to CAP defined by IB4 binding. Significantly more IB4-positive neurons respond to 500nM CAP from skin-only incised mice than sham mice (overall effect: p = 0.0007; ***p = 0.0003). There is no difference in CAP responsiveness in IB4-negative neurons from incised and sham mice. Same neurons as in Figure 6a.