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Figure 1 | Molecular Pain

Figure 1

From: Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation

Figure 1

Specimen recordings of unitary activity from the saphenous nerve. Action potentials evoked by electrical stimulation applied on the receptive field (Aa, Ba, Ca). A red triangle indicates the onset of electrical stimulation and a filled circle indicates a peak of recorded action potential. Conduction velocity (CV) was calculated based on a latency and an interelectrode distance. Mechanical threshold (Th) was measured by stimulating the receptive field of the recorded unit with von Frey filaments. Superimposed action potentials during a trial of microcone touch (Ab, Bb, Cb). Recording of each afferent unit activity in responses to a 10-min touch using a microcone (left) and flat disc (right) (Ac, Bc). For C afferent unit activity, only an enlarged view at the onset of touch is presented and the action potentials of the unit are indicated by filled circles (Cc). The histogram illustrates the discharge rate every second (Ad, Bd, Cd). A horizontal line below each histogram indicates a period of touch (10 min).

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