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Figure 4 | Molecular Pain

Figure 4

From: Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation

Figure 4

Influence of opioid receptor antagonists on the effect of microcone touch. Averages of changes in heart rate (HR) response to heat stimulation (A, C, E) and basal HR (B, D, F) before, during, and after touch in rats injected with naloxone, CTOP, and naltrindole, respectively. The influence of i.t.-injected drugs on the effect of touch on heat-induced HR response and basal HR was examined using a 3 × 4 mixed model ANOVA followed by the Bonferroni’s multiple comparison test; “conditions” (pre-touch, during touch, and post-touch) as the within-subject factor and “drugs” (saline, naloxone, CTOP, and naltrindole) as the between-subject factor. The analysis shows that a significant interaction was observed in HR response (p = 0.02), but not basal HR (p = 0.20). See Figure 3 for further details.

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Molecular Pain

ISSN: 1744-8069

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