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Figure 3 | Molecular Pain

Figure 3

From: Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results

Figure 3

Survival of transplanted GDNF/EGFP-MSCs in the non-injured DRGs. Integrated GDNF/EGFP-MSCs are shown residing in extracellular spaces within DRGs at 1 week (A) and 2 weeks (B) post-transplantation using GDNF and GFP antibodies. High-power image (C) of DRG 2 weeks after transplantation reveals high expression of GDNF and GFP in fibroblast-like GDNF/EGFP-MSCs while the endogenous GDNF immunofluorescent (IF) signals are detected as ‘glia-rings’ around neurons and variably in neurons. Double immunostaining 2 weeks after transplantation shows that the grafted GDNF/EGFP-MSCs are immunopositive for STRO-1 (D) but immunonegative for Tubb3 (E), GS (F), and GFAP (G). In C-G, the filled arrowheads denote engrafted GDNF/EGFP-MSCs, while the empty arrowheads indicate endogenous markers. Scale bar = 50 μm for all images.

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Molecular Pain

ISSN: 1744-8069

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