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Figure 5 | Molecular Pain

Figure 5

From: Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results

Figure 5

Tumor-like aggregation of transplanted MSCs within DRG. (A, B) Representative images from one of the DRGs in which MSC transplantation led to development of a mass show hematoxylin & eosin (H&E) stains of a tumor-like mass in a DRG from a EGFP MSC recipient rat (SNL), revealing a hypercellular aggregations of MSCs consisting of pleomorphic cells, with normal sensory neuron somata and axons mostly surrounding the mass (A) but also some dispersed within the MSC stroma (B, arrows). Immunohistochemical examination shows the cellular nodule is composed of EGFP-positive cells that are negative for TUBB3 (C, outlined area magnified in D, arrows point TUBB3-positive neurons) and GFAP (E, outlined area magnified in F). These MSCs express high level of PCNA (G) and immunopositivity for Bax (H). Scale bars: A-F = 100 μm, G, H = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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