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Figure 7 | Molecular Pain

Figure 7

From: Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40

Figure 7

Effects of GW1100 on inflammatory and neuropathic pain-like behaviors. (A) Effect of intrathecal (i.t.) injection of GW1100 on carrageenan (Car)-induced thermal hyperalgesia. The GPR40 antagonist, GW1100, was injected 6 hours after carrageenan injection. (B, C) Effects of intrathecal injection of GW1100 on CFA (B)- and SNL (C)-induced mechanical allodynia. Paw withdrawal latency to thermal stimuli (A) or paw withdrawal threshold to mechanical stimulation (B, C) are plotted against the time after carrageenan injection into a hindpaw (A) or after intrathecal injection of GW1100 (B, C). Data are mean ± SEM. ** P < 0.01, *** P < 0.001, compared with pre-drug (at 0 hour) data (one-way ANOVA followed by Dunnett’s post hoc test).

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